CoQ10 Medical Studies

Of the thousands of scientific studies on the research and clinical study focused on the biochemistry and health benefits of CoQ10 published worldwide over the past thirty years, the majority have been conducted using Kaneka CoQ10™, the precursor of WIN CoQ10.

Aging
Field	Title	Author	Journal
1	Human aging and global function of coenzyme Q10.	Linnane AW, et al.	Ann. N. Y. Acad. Sci. 2002; 959:396-411
2	Role of mitochondria in oxidative stress and aging	Lenaz G, et al.	Ann. N. Y. Acad. Sci. 2002; 959:199-213
3	Coenzyme Q10, a cutaneous antioxidant and energizer.	Hoppe U, et al.	Biofactors. 1999; 9(2-4):371-8
4	Mitochondrial aging: open questions.	Beckman KB, et al.	Ann. N. Y. Acad. Sci. 1998; 854:118-27
5	Age-related changes in the lipid compositions of rat and human tissues.	Kalen A, et al.	Lipids. 1989; 24(7):579-84

Alzheimer's Disease
Field	Title	Author	Journal
1	Serum levels of coenzyme Q10 in patients with Alzheimer's disease.	de Bustos F, et al.	J. Neural Transm. 2000; 107(2):233-9
2	Muscle biopsy in Alzheimer's disease: morphological and biochemical findings.	Mariani C, et al.	Clin. Neuropathol. 1991; 10(4): 171-6

Amyotrophic Lateral Sclerosis (ALS) Lou Gehrig's Disease
Field	Title	Author	Journal
1	Coenzyme Q10 as a possible treatment for neurodegenerative disease.	Beal MF.	Free Radic. Res. 2002; 36(4): 455-60
2	Serum levels of coenzyme Q10 in patients with amyotrophic lateral sclerosis.	Molina JA, et al.	J. Neural Transm. 2000; 107 (8-9):1021-6
3	Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects.	Matthews RT, et al.	Proc. Natl. Acad. Sci. U. S. A. 1998; 95(15):8892-7
4	Tolerance of high-dose (3,000) mg/day) coenzyme Q10 in ALS	K.L.Ferrante, et al.	Neurology (Neurology Vol.65: 11: 1834-36). 2005, American Academy of Neurology

Antioxidant Function
Field	Title	Author	Journal
1	Effect of dicumarol, a NAD(P)H: quinone acceptor oxido-reductase (DT-diaphorase) inhibitor on ubiquinone redox cycling in cultured rat hepatocytes.	Kishi T, et al.	Free Radic. Res. 2002; 36(4): 413-9
2	Mechanisms of antioxidant action of ubiquinol-10 for low- density lipoprotein.	Thomas SR, et al.	in Coenzyme Q: Molecular Mechanism 2001; 131-150
3	Coenzyme Q10 enrichment decreases oxidative DNA damage in human lymphocytes.	Tomasetti M, et al.	Free Radic. Biol. Med. 1999; 27(9-10):1027-32
4	Expansion of antioxidant function of vitamin E by coenzyme Q.	Quinn PJ, et al.	Biofactors. 1999; 9(2-4):149-154
5	Biochemical, physiological and medical aspects of ubiquinone function.	Ernster L, et al.	Biochim. Biophys. Acta. 1995; 1271(1):195-204
6	Antioxidative effect of dietary coenzyme Q10 in human blood plasma.	Weber C, et al.	Int. J. Vitam. Nutr. Res. 1994; 64(4):311-5

Atherosclerosis
Field	Title	Author	Journal
1	Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice.	Thomas SR, et al.	Arterioscler. Thromb. Vasc. Biol. 2001; 21(4):585-93
2	Anti-atherogenic effect of coenzyme Q10 in apolipoprotein E gene knockout mice.	Witting PK, et al.	Free Radic. Biol. Med. 2000; 29(3-4):295-305
3	Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation.	Mohr D, et al.	Biochem. Biophys. Acta. 1992; 1126(3):247-54

Cancer
Field	Title	Author	Journal
1	Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients.	Portakal O, et al.	Clin. Biochem. 2000; 33(4):279-84
2	CoQ10: could it have a role in cancer management?	Hodges S, et al.	Biofactors. 1999; 9(2-4):365-70
3	Activities of vitamin Q10 in animal models and a serious deficiency in patients with cancer.	Folkers K, et al.	Biochem. Biophys. Res.. Commun. 1997; 234(2):296-9
4	Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases.	Lockwood K, et al.	Biochem. Biophys. Res. Commun. 1995; 212(1):172-7
5	Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10.	Lockwood K, et al.	Biochem. Biophys. Res. Commun. 1994; 199(3):1504-8
6	Survival of cancer patients on therapy with coenzyme Q10.	Folkers K, et al.	Biochem. Biophys. Res. Commun. 1993; 192(1):241-5

Diabetes
Field	Title	Author	Journal
1	Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes.	Hodgson JM, et al.	Clin. Biochem. 2000; 33(4):279-84
2	Coenzyme Q10 improves endothelial dysfunction of the brachial artery in Type 2 diabetes mellitus.	Watts GF, et al.	Biofactors. 1999; 9(2-4):365-70
3	The effect of coenzyme Q10 administration on metabolic control type 2 diabetes mellitus.	Eriksson JG, et al.	Biochem. Biophys. Res.. Commun. 1997; 234(2):296-9
4	Impact of ubiquinone (coenzyme Q10) treatment on glycaemic control, insulin requirement and well-being in patients with Type 1 diabetes mellitus.	Henriksen JE, et al.	Biochem. Biophys. Res. Commun. 1995; 212(1):172-7
5	The effect of coenzyme Q10 treatment on maternally inherited diabetes mellitus and deafness, and mitochondrial DNA 3243 (A to G) mutation.	Suzuki S, et al.	Biochem. Biophys. Res. Commun. 1994; 199(3):1504-8
6	Plasma ubiquinol/cholesterol ratios in patients with hyperlipidaemia, those with diabetes mellitus and in patients requiring dialysis.	McDonnell MG, et al.	Biochem. Biophys. Res. Commun. 1993; 192(1):241-5

Energy
Field	Title	Author	Journal
1	Biochemical functions of coenzyme Q10.	Crane FL.	J. Am. Coll. Nutr. 2001; 20(6):591-8
2	Coenzyme Q: potentially useful index of bioenergetic and oxidative status of spermatozoa.	Angelitti AG, et al.	Clin. Chem. 1995; 41(2):217-9
3	Antifatigue effects of coenzyme Q10 during physical fatigue.	Mizuno K, et al.	Nutrition. 2008 Feb 11. Published online ahead of print.

Friedreich’s Ataxia
Field	Title	Author	Journal
1	Coenzyme Q10 and idebenone in the therapy of respiratory chain diseases: rationale and comparative benefits.	Geromel V, et al.	Mol. Genet. Metab. 2002; 77(1-2):21-30
2	Antioxidant treatment improves in vivo cardiac and skeletal muscle bioenergetics in patients with Friedreich's ataxia.	Lodi R, et al.	Ann. Neurol. 2001; 49(5):590-6

Heart Disease
Field	Title	Author	Journal
1	Role of coenzyme Q10 in chronic heart failure, angina, and hypertension.	Tran MT, et al.	Pharmacotherapy. 2001; 21(7):797-806
2	Coenzyme Q10 treatment in serious heart failure.	Munkholm H, et al.	Biofactors. 1999; 9(2-4):285-9
3	Overview of the use of CoQ10 in cardiovascular disease.	Langsjoen PH, et al.	Biofactors. 1999; 9(2-4):273-84
4	Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 Study Group.	Hofman-Bang C,et al .	J. Card. Fail. 1995; 1(2):101-7
5	Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study.	Morisco C, et al.	Clin. Investig. 1993; 71(8 Suppl):s134-6
6	A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10.	Langsjoen PH, et al.	Int. J. Tissue React. 1990; 12(3):169-71
7	Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10.	Folkers K, et al.	Proc. Natl. Acad. Sci. U. S. A. 1985; 82(3):901-4

High Blood Pressure Hypertension
Field	Title	Author	Journal
1	Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes.	Hodgson JM, et al.	Eur. J. Clin. Nutr. 2002; 56(11):1137-42
2	Treatment of essential hypertension with coenzyme Q1.	Langsjoen P, et al.	Mol. Aspects Med. 1994; 15 Suppl:s265-72

Huntington's Disease
Field	Title	Author	Journal
1	Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.	Ferrante RJ, et al.	J. Neurosci. 2002; 22(5):1592-9
2	A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease.	Huntington Study Group	Neurology. 2001; 57(3):397-404
3	Energy metabolism defects in Huntington's disease and effects of coenzyme Q1.	Koroshetz WJ, et al.	Ann. Neurol. 1997; 41(2):160-5

Immune System
Field	Title	Author	Journal
1	Coenzyme Q10 in vesicles composed of archaeal ether lipids or conventional lipids enhances the immuno-adjuvanticity to encapsulated protein.	Makabi-Panzu B, et al.	Vaccine. 1998; 16(16):1504-10
2	The activities of coenzyme Q10 and vitamin B6 for immune responses.	Folkers K, et al.	Biochem. Biophys. Res. Commun. 1993; 193(1):88-92

Muscular Dystrophy
Field	Title	Author	Journal
1	Coenzyme Q10, exercise lactate and CTG trinucleotide expansion in myotonic dystroph.	Siciliano G, et al.	Brain Res. Bull. 2001; 56(3-4):405-10
2	Potential involvement of ubiquinone in myotonic dystrophy pathophysiology: new diagnostic approaches for new rationale therapeutics.	Tedeschi D, et al.	Neurol. Sci. 2000; 21(5 Suppl):s979-80
3	Two successful double-blind trials with coenzyme Q10 muscular dystrophies and neurogenic atrophies.	Folkers K, et al.	Biochim. Biophys. Acta. 1995; 1271(1):281-6

Parkinson's Disease
Field	Title	Author	Journal
1	Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease.	Muller T, et al.	Neurosci. Lett. 2003; 341(3):201-4
2	Effects of Coenzyme Q10 in Early Parkinson Disease: evidence of slowing of the functional decline.	Shults CW, et al.; Parkinson Study Group.	Arch. Neurol. 2002; 59(10):1541-50

Periodontal Disease
Field	Title	Author	Journal
1	Coenzyme Q10 and periodontal treatment: is there any beneficial effect?	Watts TL, et al.	Br. Dent. J. 1995; 178(6):209-13
2	Effect of topical application of coenzyme Q10 on adult periodontitis.	Hanioka T, et al.	Mol. Aspects Med. 1994; 15 Suppl:s241-8
3	Therapy with coenzyme Q10 for patients with periodontal disease.	Mcree JT, et al.	J. Dent. Heal. 1993; 43:659-66
4	Clinical effect of coenzyme Q10 on periodontal disease.	Iwamoto Y, et al.	in Biomedical and Clinical Aspects of CoQ: Elsevier 1981; 3:109-19
5	Bioenergetics in clinical medicine.VI. adjunctive treatment of periodontal disease with coenzyme Q10.	Wilkinson EG, et al.	Res. Commun. Chem. Pathol. Pharmacol. 1976; 14(4):715-9

Statins
Field	Title	Author	Journal
1	Statins and coenzyme Q10.	Ellis CJ, et al.	Lancet 2003; 361(9363):1134-5
2	ACC/AHA/NHLBI clinical advisory on the use and safety of statins.	Pasternak RC, et al.	J. Am. Coll. Cardiol. 2002; 40(3):567-72
3	Statins and myopathy.	Hargreaves IP, et al.	Lancet 2002; 359(9307):711-2
4	Biochemical and clinical consequences of inhibiting CoQ10 biosynthesis by lipid-lowering HMG-CoA reductase inhibitors (statins): a critical overview.	Bliznakov EG, et al.	Adv. Ther. 1998; 15(4):218-28
5	Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study.	Ghirlanda G, et al.	J. Clin. Pharmacol. 1993; 33(3):226-9

Sporting Activity
Field	Title	Author	Journal
1	Effect of ubidecarenone oral treatment on aerobic power in middle-aged trained subjects.	Bonetti A, et al.	J. Sports Med. Phys. Fitness. 2000; 40(1):51-7
2	Effects of ubiquinone-10 supplementation and high intensity training on physical performance in humans.	Malm C, et al.	Acta Physiol. Scand. 1997; 161(3):379-84
3	Ubiquinone supplementation and exercise capacity in trained young and older men.	Laaksonen R, et al.	Eur. J. Appl. Physiol. Occup. Physiol. 1995; 72(1-2):95-100
4	Influence of coenzyme-Q10 on physical work capacity in athletes, sedentary people and patients with mitochondrial disease.	Zeppili P, et al.	in Biomedical and Clinical Aspects of CoQ: Elsevier. 1991; 6:541-5
5	Effect of CoQ10 on the Metabolic Response to Work.	Cerioli G, et al.	in Biomedical and Clinical Aspects of CoQ: Elsevier. 1991; 6:521-4
6	Metabolic effects of coenzyme Q10 treatment in high level athletes.	Fiorella PL, et al.	in Biomedical and Clinical Aspects of CoQ: Elsevier. 1991; 6:513-20
7	Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals.	Matthew Cooke, et al.	Journal of the International Society of Sports Nutrition 2008, 5:8doi:10.1186/1550-2783-5-8

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WIN CoQ10 - 100% Pure Ubiquinol CoQ10, or coenzyme Q10, is a powerful vitamin-like substance naturally produced in all cells of the human body, and has been studied extensively for more than 30 years. Research indicates CoQ10 supplementation may support normal heart function, protect DNA from free radical induced oxidative damage and help maintain healthy energy levels. WIN CoQ10 contains 50mg of the most advanced, high-absorption form of CoQ10 available, ubiquinol. This formulation is the first supplemental form of bio-identical ubiquinol ever developed and is derived from the world’s purest, most thoroughly researched CoQ10. Coenzyme Q10 acts much like a spark plug for each of your body’s cells playing a vital role in energy production, but additionally, this ubiquinol form is an active antioxidant protecting the body’s cells from damage caused by oxidative stress and free radicals. Retail Price - $65.00 Add to shopping cart